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Tramadol (brand name: Ultram) is an opioid analgesic (painer). [Posted 08/31/2016]AUDIENCE: Pharmacy, Internal Medicine, Psychiatry, Neurology, Family Practice ISSUE: FDA review has found that the growing combined use of opioid medicines with benzodiazepines or other drugs that depress the central nervous system (CNS) has resulted in serious side effects, including slowed or difficult breathing and deaths.