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Tramadol - pedia Tramadol was launched and marketed as "Tramal" by the German pharmaceutical company Grünenthal Gmb H in 1977 in West Germany, and 20 years later it was launched in countries such as the UK, US, and Australia. Tramadol, sold under the brandname Ultram among others, is an opioid pain medication used. Those with decreased CYP2D6 activity require a dose increase of 30% in order to achieve the same degree of pain relief as those with a normal.
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